تاٴثیر فلوکستین بر میزان مصرف غذا و رفتار غذایی در ماهی طلایی Carassius auratus

نوع مقاله : مقاله پژوهشی

نویسندگان

چکیده

سروتونین از جمله مونوآمین­هایی است که نقش بالقوه­ای در تنظیم مصرف غذا در پستانداران دارد و هر عاملی که بتواند فعالیت سروتونرژیک را افزایش دهد باعث کاهش اشتها می­گردد. فلوکستین به عنوان ماده مؤثر داروی پروزاک با بلوکه کردن بازجذب سروتونین، موجب افزایش آن شده و با توجه به ورود این ماده به اکوسیستم­های آبی به عنوان یک ماده آلاینده مطرح است. در این مطالعه نقش فلوکستین در میزان مصرف غذا و رفتار تغذیه­ای ماهی طلایی، Carassius auratus بررسی گردید. در آزمایش 1، ماهیان با وزن 49-21 گرم در چهار گروه تقسیم شدند. گروه کنترل: بدون هیچ­گونه تزریق؛ گروه تزریق شده با سرم فیزیولوژیک؛ و گروه­های تزریق شده با µg g-1 1 و  µg g-1 10 وزن بدن فلوکستین که در 5 نوبت به صورت یک روز در میان تزریق شدند. میزان مصرف غذا بعد از هر تزریق محاسبه شد و در نهایت تغییرات وزنی تیمارها نیز بررسی گردید. در آزمایش 2، تعداد 20 عدد ماهی طلایی در دو گروه برای آزمون رفتاری انتخاب شدند که شامل گروه کنترل و گروه تزریق شده با µg g-110 وزن بدن فلوکستین بودند که در 5 نوبت به صورت یک روز در میان تزریق شدند. بعد از هر تزریق رفتارهای تغذیه­ای نمونه­ها بررسی شد. نتایج نشان داد که فلوکستین باعث کاهش معنادار مصرف غذا در ماهیان می­شود. کاهش مصرف غذا، کاهش معنادار وزن­گیری را در گروه Flu-10 به دنبال داشت. همچنین فلوکستین بر رفتار غذایی ماهی طلایی مؤثر بوده و میل به جستجو و مصرف طعمه را بطور معنی­دار کاهش داد. این مطالعه نقش بالقوه یکی از داروهای انسانی را بر فاکتورهای تغذیه­ای یک ماهی استخوانی مشخص کرده و نشان می­دهد که فلوکستین می­تواند فاکتورهای غذایی و رشدی را در ماهی طلایی تحت تاٴثیر قرار دهد.

کلیدواژه‌ها


عنوان مقاله [English]

Effect of fluoxetine on food intake and feeding behavior of Goldfish Carassius auratus

نویسندگان [English]

  • N. Forsatkar
  • K. Kukaram
  • M.A. Nematolahi
چکیده [English]

Serotonin is one of the monoamines that play an important role in food intake in mammalian species. The increase in serotonergic activity may reduce appetite. Fluoxetine as an active ingredient of Prozac is increased in serotonin content by blocking reuptake of it. Due to the release of these substances into the ecosystem, the role of fluoxetine on food intake and feed behavior of goldfish, Carassius auratus was investigated. In experiment 1, fish with 21-49 g weight divided in four groups of control: with no injection; saline injected; and two groups with 1 µg g-1 and 10 µg g-1 body weight fluoxetine. Animals were injected every other day for a total of 5 injections. Food intake calculated after each injection and fish reweighted at the end of the experiment to achieved weight changes. In experiment 2, 20 goldfish were selected in two groups of control and injected with 10 µg g-1 body weight fluoxetine to asses feed behavior test. Fish were injected every other day for a total of 5 injections and feed behavior was investigated after each injection. Food intake was significantly decreased after fluoxetine injections. In the Flu-10 group, low intake of food resulted in minimum weight gain among all treatments. Also, fluoxetine affected the feed behavior of goldfish and significantly was decreased in search and consumption of food. Results showed that this recently toxic environmental material can largely affect the food and weight parameters of goldfish.

کلیدواژه‌ها [English]

  • Fluoxetine
  • Goldfish
  • IP injection
  • Food intake
  • FEEDING BEHAVIOR
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